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PRBB-CRG Sessions
Scientific sessions of the PRBB centres funded by the Centre for Genomic Regulation (CRG) and the Barcelona Biomedical Research Park
28/04/202312:00MARIE CURIEPRBB-CRG SessionsKatrin Andreasson + Philip BeachyStanford Medicine”Immune-metabolic mechanisms of cognitive decline in aging” + “Mechanisms of Hedgehog signaling in regeneration and malignancy”Host: Thomas GrafAbstract:”Immune-metabolic mechanisms of cognitive decline in aging”
Aging is characterized by the development of persistent pro-inflammatory responses that promote multiple age-dependent diseases. The aging brain is also vulnerable to inflammation, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer’s dementia (AD), where human genetics implicate disrupted innate immune responses in its development. We…
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12/05/202312:00MARIE CURIEPRBB-CRG SessionsNick J. ProudfootSir William Dunn School of Pathology, University of Oxford UK“Nascent transcription and coupled RNA processing of human protein coding and long noncoding genes”Host: Juan ValcárcelAbstract:We have developed technology to characterise nascent transcription synthesised by RNA polymerase II in human cell lines. Using the POINT-seq procedure (Sousa-Luis et al. Mol Cell 2021; doi.org/10.1016/j.molcel.2021.02.034) we show that protein coding (pc) and long noncoding (lnc) transcripts are synthesised and processed distinctly. This leads to rapid splicing of pc gene transcripts (pre-mRNA) or…
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26/05/202312:00MARIE CURIEPRBB-CRG SessionsDavid M. GilbertLaboratory of Chromosome Replication and Epigenome Regulation, San Diego Biomedical Research Institute, CA, USA”Regulation of Replication Timing and Chromosome Architecture”Host: Roderic GuigóAbstract:The mammalian genome is replicated in a defined temporal sequence during S phase of each cell cycle known as the replication timing program.
Since chromatin is assembled at the replication fork, and different types of chromatin are assembled at different times, replication timing is positioned to be central to maintenance or alteration of chromatin states. We have found that replication timing is a highly stable cell-type…
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02/06/202312:00MARIE CURIEPRBB-CRG SessionsLiam HoltAssociate Professor, Institute for Systems Genetics, New York University School of Medicine, USA”Crowding, compression, and condensation”Host: Elvan BökeAbstract:Thousands of biochemical reactions occur simultaneously in the cell. Small molecules are channeled through metabolic pathways at blistering speed. Giant complexes assemble to orchestrate transcription and translation. ATP fuels the active transport of organelles along microtubules, and actin networks drive membrane remodeling and agitate the cytoplasm. All of this occurs within a crowded cell interior that approaches the physical limits where molecular jamming and…
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16/06/202312:00MARIE CURIEPRBB-CRG SessionsHenrique Veiga-FernandesImmunophysiology Group, Champalimaud Centre for the Unknown, Lisbon, Portugal”Neuroimmune interactions in health and disease”Host: Pia Cosma
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07/07/202312:00MARIE CURIEPRBB-CRG SessionsDirk SchubelerFMI, Basel, Switzerland”tbd”Host: Renee Beekman
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20/10/202312:00MARIE CURIEPRBB-CRG SessionsKikue TachibanaMax Planck Institute of Biochemistry, München, Germany”tbd”Host: Elvan Böke
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17/11/202312:00MARIE CURIEPRBB-CRG SessionsKyle GaultonDepartment of Pediatrics, University of California, San Diego, USA”tbd”Host: Jorge Ferrer
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15/12/202312:00MARIE CURIEPRBB-CRG SessionsCeline VallotInstitut Curie, Paris, France”tbd”Host: Renee Beekman
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The Prbb Foundation – Nonprofit Explorer
Total Revenue |
$560,390 |
|
|---|---|---|
| Total Expenses | $278,858 | |
| Notable sources of revenue | Percent of total revenue | |
| Contributions received | $0 | |
| Interest revenue | $7,198 |
1. 3%
|
| Dividends | $28,749 | 5.1% |
| Sales of assets | $524,443 | 93.6% |
| Other income | $0 | |
| Notable expenses | Percent of total expenses* | |
| Charitable disbursements | $266,788 | 95.7% |
| Compensation of officers* | $0 | |
| Other | ||
| Total Assets | $2,480,368 | |
| Total Liabilities | $1 | |
* Officer compensation may be included in charitable disbursements, so values may add up to greater than 100%. |
||
| Key Employees and Officers | Compensation |
|
LOUISE DAVIS (PRESIDENT) |
$0 |
|
JEANETTE HAGEN (VICE PRESIDE) |
$0 |
|
MOLLY HAMPTON (TRUSTEE) |
$0 |
|
JONATHAN DAVIS (TRUSTEE) |
$0 |
+ Show more
26. Relay panels prb, prbb and prg
Relay panel
designed for power distribution
signals, track circuits, scoreboards and
control circuits arrows in all
required modes. Panel perform
in three versions:
Table 357
Name and
entry panel element type
|
Conditional |
Name |
|
-1R, |
Resistor |
|
RE |
Lamp |
|
1FB, |
Lamp |
|
1T-6T |
Transformer |
|
1D-ZD, |
Diode |
|
Sv |
Call |
|
1C, |
Counter |
|
H |
Cover |
|
PS7— |
Fuse |
|
PS1-PS6 |
That |
|
P4-P6 |
Fuse |
|
P1-PZ; |
Fuse |
|
1CT, |
Contactor |
|
3 |
Relay |
|
1F1-3; |
Relay |
|
1F, |
Relay |
|
V |
Voltmeter |
|
1A, |
Ammeter |
|
VK |
Switch |
|
1AK, |
Switch |
|
1PV, |
Switch |
|
ZPV |
Switch |
|
4PV |
Switch |
|
5PV, |
Switch |
090 A 
20876.00.00
– electric
centralized battery system type
PRB, damn.
22214.00.00;
– electric
batteryless system centralization
type PRBB, hell. 22215.00.00;
– slide
centralization type PRG, hell. 22216.00.00.
Relay
electrical interlocking panels
PRB and PRB
Nutrition
traffic lights and route indicators.
Relay
panel is powered by
installations up to 140 hands, which corresponds to
supply of 150-160 traffic lights.
Nutrition
track chains is produced
alternating current voltage 220 V
through an isolation transformer.
Possibility of powering track circuits
directly from supply feeders,
if the voltage applied to the relay
panel, and AC power
do not have grounding neutral wire
(the latter is required by the conditions
the safety of operating personnel).
In this case, the relay board
install jumpers K24-1
and
K25-1;
K24-2 and
K25-2;
K24-3 and
K25-3.
With autonomous
traction and electric traction of trains
DC track circuits
they are usually powered from one phase.
From
calculation of the power supply of all track circuits
from one phase is made and type selection
TS transformer. Food rail
circuits from one phase makes it possible
protect track circuits from coming off
insulating joints.
At stations with
number of arrows up to 50 with autonomous
traction trains as an insulating
transformer for power rail
circuits, a 2T transformer is used,
not used to power signals.
For EC posts, which include more than
50 arrows, install special
transformer outside the relay panel.
The type and power of the transformer determine
calculation and point to skeletal
power supply diagrams.
Food rail
circuits with a frequency of 25 Hz is produced from
special panels, voltage on
which comes directly from
introductory panel.
Transmitter
relay for coded track circuits
in the presence of a transformer, the vehicle receives
power supply from relay panel terminals K
18-4 and
K
18-2. At
absence of transformer TS
transmitter relays are powered by
separate transformer ZT
s
terminals K17-3,
K16-3.
Food
arrow control circuits. Relay
panels depending on their type
allow for food
control chains arrows as with
battery and batteryless
systems.
With a block system
centralization with pointer trigger
pointer control relays
type KM-3000 powered by
individual
transformers type SKT-1, located
in switch starting blocks, and
consume 9.5 W of power at voltage
127 V or 7 W at 220 V.
At
battery circuit and accident
alternating current pointer control
relays receive alternating current voltage
125 V from converters like PO-550 AF,
operating from a working battery voltage
220 V. One converter type PO-550 AF
for redundant control power supply
arrow chains can be applied on
stations with a number of turnout switches
no more than 58 or with the number of arrows up to 80.
With a larger number of switch switches
install a second converter
PO-550 AF. Parallel connection of two
load converters
power supply is allowed
control transformers should
be performed separately for two groups
shooter (power wires SHKS,
10HKS and
2PCX,
20 XKQ .
Converters
PO-550 AF are not included in the set of panels and
ordered separately.
Nutrition
scoreboard lamps. Lamps
boards are powered by a step-down
transformer IT
voltage
24 V (220/24 V, 50 A). To decrease brightness
burning scoreboard lamps at night
voltage reduction provided
up to 19.5 V, which is achieved by switching
sections of the primary winding of the transformer
IT
contact
relay SNT,
running
at the push of a button SNTK
on
remote control.
Relay
hump centralization panel PRG
IN
hump electrical interlocking
from the relay panel is carried out
power supply for indicator lamps, traffic lights,
route indicators and rail
chains. From transformer IT
lamps
scoreboard of six beams consume current
up to 21 A.
Except
display lamps from the transformer IT
eat
bulbs of ARS blocks with a current of 35 A. For
reduce transformer overload
panel of the power circuit of the lamps of the APC blocks
divided into two parts and connected
to feed 1KSH,
1KSH1, 2KSH, 2KSH1.
Bulbs
APC blocks normally from the transformer
disconnected by relay contacts 1KS,
2KS. At
the need to control the work
APC blocks by pressing one of the two
specially installed buttons
power is supplied to the appropriate
group of APC blocks.
Unlike
relay panel electrical
relay panel centralization
hump centralization can be carried out
isolation control of three batteries:
control, moderators and ARS.
HAC control battery connected
directly to the alarm
retarder batteries and ARS – through
toggle switch. Ground control
of these batteries is produced serially
connecting the negative pole with
switch to terminal “-24” signaling device
grounding.
Control
power supply ground signaling
traffic lights, route signs and
track circuits is also carried out
through toggle switches. Fine
toggle switches must be
in position controlling the power circuit
traffic lights. Shuttle power supply chains,
pointers from the transformer 2T
and
track circuits are controlled in turn.
Name
and type of elements, incoming
in relay panels PRB, PRBB and PRG,
are given in table. 358.
Table 358
Name and
relay panel element type
|
Conditional |
Name |
|
KPL |
Lamp |
|
1T |
Transformer |
|
2T-4T |
Transformer |
|
1PV-4PV |
Switch |
|
5PV |
Switch |
|
VK |
Contactor |
|
1A-ZA |
Ammeter |
|
V |
Voltmeter |
|
1TA-2TA |
Relay |
|
SNT, |
Relay |
|
1SKA |
Relay |
|
2SKA, |
Relay |
|
PP |
Relay |
|
DI |
Sensor |
|
PS2, |
Fuse |
|
PS5, |
That |
|
PS14, |
That |
24170.00.00 B 
20876.00.00
Continuation of the table.
358
|
Conditional |
Name |
|
PS1 |
That |
|
PS7, |
|
|
in |
That |
|
in |
That |
|
PS11: |
|
|
in |
That |
|
in |
That |
|
P2 |
Fuse |
|
P1: |
|
|
in |
That |
|
in |
That |
|
SW: |
|
|
in |
That |
|
in |
That |
|
DSN |
Relay |
|
1TB—6TB |
Tumbler |
|
SZ; |
|
|
for |
Signaling device |
|
for |
Signaling device |
|
Sv |
Call |
|
efficiency |
Diode |
24122.00.00
dimensions
750x550x2240mm; weight 350 kg.
Russian language – 10
Morphology
fell on the steps of a high stone porch.
5) I knew that on the very crest of the mountain the wind
will be ferocious .. even more. (From the works of A. Belyaev)
II. 6) Above the roofs of large houses, the sky began to brighten, and TV antennas
traced .. rolled in it with black strokes. 7) Then a short wind hit, and, like the first
scouts of a thunderstorm, blazed .. swirled columns of dust along the road. 8) There was a bend in the river,
and the current threw everything that floated on the right bank onto the sand. 9) All life all teams..-
bring down Yashka, and now he commands .. he came, and they obeyed him. 10) The blue morning has already leaked..was
in the crack. 11) The drummers were now standing with their heads up, as if listening .. fell: do not
Will someone from the other side answer? 12) Ilkin’s mother greeted the guests cheerfully. It is seen
was really happy.
(From the works of V. Krapivin)
III. 13) Wind swing..shaft on mountain ash with red tassels of berries, like festive ones
flags. 14) At times, the wolf cub shuddered .. shaft and somehow in a special squeal .. shaft, as if
whimpered. 15) The puppy woke up, yawned and slowly turned .. rolled his forehead to the right, but
there was no one there. 16) It was evening when the huntsman and I went down on horseback into the gorge and decided
overnight stay.. 17) The saigas stopped..came and looked around..came to the sides. (From the works
M. Zvereva)
3. Form verbs in indefinite form with suffixes from the words below
-ova- (-eva-) and -iva- (-eva-) . Explain the spelling of vowels in suffixes
verbs.
Late, feel, consider, participate, calculate, talk, use,
I ask, I try, I spend the night, I please, I advise, I knock down.
4. Specify in what cases it is necessary to write -ova-(-eva-), and in which – -iva-
(-yva-) .
Explain the spelling of suffixes.
Ventilate..dump..ventilate
demand, dance..wat, spend..wat, go..wat, evaluate..wat, preach..wat, koch..wat,
manager..
5. Form the past tense from the following verbs. Determine the spelling
a vowel before the past tense suffix -l-.
Winnow, build, hope, bark, glue, flutter, repent, offend, multiply,
cherish, hate, toil, understand, slow down.
6. Expand the brackets. Insert, where necessary, a soft sign in – and – ts.
Explain your choice.
I. I had to hurry (t, t) sya. Two kilometers later the valley suddenly became narrower (t, t) sya.
Clay shales began to fall, (t,t) . The width of the valley narrows (t,t) xia meters
up to a hundred, then expand (t, t) more than a kilometer.
Branches of the river form such
a labyrinth in which it is very easy to get lost (t,t) if you do not (t,t) keep to the main channel.
On the ridge overgrown with forest, one must walk carefully, one must often stop (t, t) sya,
examining (t,t) , otherwise it is easy to lead (t,t) astray. (V. Arseniev)
II. 1) Be able to make mistakes (t, t), be able to get better (t, t) . 2) Where is the song (t, t) sya, there
live happily (t, t) sya. 3) With smart knowledge (t, t) sya – dial the mind (t, t) sya. 4) Who
loves
work (t, t) sya, don’t sit around doing nothing (t, t) sya. 5) Two hours gathering (t, t) xia, two hours
minds-
vae(t,t)sya, dress all day (t,t) sya. 6) Look after beauty (t, t) sya, and use the mind (t, t,) sya.